{"product_id":"d-type-cyclins-and-cancer-hardcover","title":"D-Type Cyclins and Cancer - Hardcover","description":"\u003cdiv\u003e\u003cp style=\"text-align: right;\"\u003e\u003ca href=\"https:\/\/reportcopyrightinfringement.com\/\" target=\"_blank\" rel=\"nofollow\"\u003e\u003cb\u003eReport copyright infringement\u003c\/b\u003e\u003c\/a\u003e\u003c\/p\u003e\u003c\/div\u003e\u003cp\u003eby \u003cb\u003ePhilip W. Hinds\u003c\/b\u003e (Editor), \u003cb\u003eNelson E. Brown\u003c\/b\u003e (Editor)\u003c\/p\u003e\u003cp\u003eProvides emphasis on functional aspects of D-type cyclins on mammalian tissue Reviews existing mouse models of cyclin D-deficiency Discusses potential of D-type cyclins as feasible therapeutic cancer targets\u003c\/p\u003e\u003ch3\u003eBack Jacket\u003c\/h3\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eThis volume provides an integrated account of our current understanding of the functions of D-type cyclins during development and tumorigenesis, with special emphasis on the kinase-independent functions of these proteins. The volume will provide a thorough review of the latest discoveries on the new functions and interacting partners of mammalian cyclin Ds crucial to explain their oncogenic and differentiation properties in different cellular contexts. The volume begins with a historical perspective of how D-type cyclins were first discovered and eventually cloned from cancer tissues, followed by an account on the canonical functions of cyclin Ds during the G1-S transition of the cell cycle. Several chapters will be devoted to review the functions of D-type cyclins as transcriptional regulators and the mechanisms through which these novel functions could impact the tumorigenic process. Also discussed is emerging evidence that pointsto a role of D-type cyclins, particularly cyclin D1, as a cytoplasmic regulator of various cellular functions. This property, in human cells at least, is traceable to certain splice isoforms with novel oncogenic implications. Finally, a chapter is devoted to recent efforts to revise the canonical view of the \"retinoblastoma pathway\" to incorporate new evidence that suggests that cyclin D1's role in G1 is to singly-phosphorylate the retinoblastoma protein (pRb) for discrimination of target protein interactions. This work represents a significant departure from the view of cyclin D1 as a negative regulator of pRb and may have critical implications for understanding the function of antineoplastic agents that target the cyclin D1-associated kinases.\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003ch3\u003eAuthor Biography\u003c\/h3\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePhilip W. Hinds\u003c\/b\u003e is Professor and Chair of the Department of Developmental, Molecular and Chemical Biology at Tufts University School of Medicine. He is also the Deputy Director of Tufts Medical Cancer Center. Dr. Hinds is an expert in cell cycle control and its dysregulation in cancer cells. He participates in several journal editorial boards including the \u003ci\u003eJournal of Biological Chemistry, \u003c\/i\u003ethe \u003ci\u003eChinese Journal of Cancer\u003c\/i\u003e, and \u003ci\u003eCancer Research \u003c\/i\u003eto name a few. \u003c\/p\u003e\u003cp\u003e\u003cb\u003eNelson E. Brown\u003c\/b\u003e is currently Associate Professor at the University of Talca School of Medicine in Chile. He is also Director of the Center for Medical Research at the University of Talca.​ His current work focuses on the role of cyclin D1-associated kinase activity in senescence and tumorigenesis\u003cbr\u003e\u003c\/p\u003e\n            \u003cdiv\u003e\n\u003cstrong\u003eNumber of Pages:\u003c\/strong\u003e 152\u003c\/div\u003e\n            \u003cdiv\u003e\n\u003cstrong\u003eDimensions:\u003c\/strong\u003e 0.44 x 9.21 x 6.14 IN\u003c\/div\u003e\n            \u003cdiv\u003e\n\u003cstrong\u003eIllustrated:\u003c\/strong\u003e Yes\u003c\/div\u003e\n            \u003cdiv\u003e\n\u003cstrong\u003ePublication Date:\u003c\/strong\u003e October 18, 2017\u003c\/div\u003e\n            ","brand":"BooksCloud","offers":[{"title":"Default Title","offer_id":46311728251077,"sku":"9783319644493","price":192.31,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0757\/6718\/5605\/files\/900-Zl8sTd9783319644493.webp?v=1780608089","url":"https:\/\/selloorium.com\/products\/d-type-cyclins-and-cancer-hardcover","provider":"Selloorium","version":"1.0","type":"link"}