{"product_id":"electron-gated-ion-channels-with-amplification-by-nh3-inversion-resonance-hardcover-1","title":"Electron-Gated Ion Channels: With Amplification by Nh3 Inversion Resonance - Hardcover","description":"\u003cdiv\u003e\u003cp style=\"text-align: right;\"\u003e\u003ca href=\"https:\/\/reportcopyrightinfringement.com\/\" target=\"_blank\" rel=\"nofollow\"\u003e\u003cb\u003eReport copyright infringement\u003c\/b\u003e\u003c\/a\u003e\u003c\/p\u003e\u003c\/div\u003e\u003cp\u003eby \u003cb\u003eWilson P. Ralston\u003c\/b\u003e (Author)\u003c\/p\u003e\u003cp\u003e\u003c\/p\u003e\u003cp\u003eUnderstanding ion channel gating has been a goal of researchers since Hodgkin and Huxley's classic publication in 1952, but the gating mechanism has remained elusive. In this book it is shown how electrons can control gating. Introducing the electron as a gating agent requires amplification, but until now there has been no appropriate mechanism for amplification.\u003c\/p\u003e \u003cp\u003eIt was discovered that NH\u003csub\u003e3\u003c\/sub\u003e groups, at the end of arginine and lysine side chains, act as amplifiers for electron tunneling. The amplification is about 25-fold, due to the inversion of NH\u003csub\u003e3\u003c\/sub\u003e. The inversion frequency for NH\u003csub\u003e3\u003c\/sub\u003e attached to the side chain was calculated from an electron-gating model, calibrated to the Hodgkin-Huxley model. It was also determined experimentally in Blue Fluorescent Protein, using a new microwave spectroscopy technique developed specifically for this purpose. The inversion frequency of NH\u003csub\u003e3\u003c\/sub\u003e in the gas phase occurs at about 24 GHz and is used by the ammonia clock and for amplification in the ammonia maser. This frequency, reduced by the attachment of NH\u003csub\u003e3\u003c\/sub\u003e to the side chain, is the basis for amplification of electron tunneling at arginine and lysine sites. Detailed models for electron gating in sodium and potassium ion channels are described and an electron-gating model for calcium oscillators is presented.\u003c\/p\u003e \u003cp\u003eThe book is a documentation of the author's research and is oriented towards research workers in the biological sciences. The new quantum-mechanical approach to ion channel gating elucidates mechanisms important to cellular function and signaling.\u003c\/p\u003e\n            \u003cdiv\u003e\n\u003cstrong\u003eNumber of Pages:\u003c\/strong\u003e 208\u003c\/div\u003e\n            \u003cdiv\u003e\n\u003cstrong\u003eDimensions:\u003c\/strong\u003e 0.78 x 9.28 x 6.26 IN\u003c\/div\u003e\n            \u003cdiv\u003e\n\u003cstrong\u003eIllustrated:\u003c\/strong\u003e Yes\u003c\/div\u003e\n            \u003cdiv\u003e\n\u003cstrong\u003ePublication Date:\u003c\/strong\u003e June 30, 2005\u003c\/div\u003e\n            ","brand":"BooksCloud","offers":[{"title":"Default Title","offer_id":45884940976325,"sku":"9781891121418","price":157.5,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0757\/6718\/5605\/files\/zjb0oxvqP29781891121418_69eb3c6d-e957-45f3-9ca1-e2e32baf7b10.webp?v=1771844168","url":"https:\/\/selloorium.com\/products\/electron-gated-ion-channels-with-amplification-by-nh3-inversion-resonance-hardcover-1","provider":"Selloorium","version":"1.0","type":"link"}